ACE 031

🧪 ACE-031 Peptide (ActRIIB-IgG1-Fc) – Research Grade Lyophilized Powder

🔬 Product Overview

ACE-031 peptide, also referred to as ActRIIB-IgG1-Fc, is a recombinant fusion protein designed for advanced scientific research. It combines the extracellular domain of activin receptor type IIB (ACVR2B) with an IgG1 Fc fragment, forming a soluble receptor capable of binding ligands from the transforming growth factor-beta (TGF-β) superfamily.

Research indicates that ACE-031 may function as a myostatin inhibitor, potentially modulating pathways involved in skeletal muscle growth, metabolic regulation, and bone density.

🧬 Mechanism of Action

ACE-031 is believed to act by binding circulating ligands such as myostatin (GDF8), preventing them from interacting with native ACVR2B receptors.

This mechanism may:

Reduce myostatin signaling pathways (Smad2/3)

Support muscle hypertrophy signaling

Influence fat metabolism and energy utilization

Contribute to bone remodeling processes

📊 Key Research Insights

💪 Muscle Growth & Hypertrophy

Observed increase in lean body mass (~3.3%)

Increase in muscle volume (~5.1%)

Potential activation of skeletal muscle growth pathways

🔥 Fat Metabolism

May promote fatty acid oxidation (CPT1a, CPT2 expression)

Potential reduction in adipose tissue accumulation

Possible induction of brown/beige fat activity

⚡ Muscle Performance

Increased contractile force (up to 40% in models)

Enhanced energy expenditure and oxygen consumption

Potential protection against oxidative stress in muscle tissue

🦴 Bone Density Support

Increased bone volume (up to ~80% in studies)

Improved bone strength and structural integrity

Possible stimulation of osteoblast activity and reduction of osteoclasts

⚗️ Chemical Information

Molecular Formula: C3418H5188N928O1062S38

Molecular Weight: 77,489.82 g/mol

Structure: Recombinant fusion protein (ACVR2B + IgG1 Fc)

Form: Lyophilized (freeze-dried) powder

Purity: Research grade

🧪 Applications (Research Use Only)

This peptide is widely used in laboratory and preclinical research for:

Myostatin pathway studies

Muscle growth and regeneration research

Metabolic disorder models

Obesity and fat metabolism studies

Bone density and musculoskeletal research

📦 Storage & Handling

Store at -20°C or below for long-term stability

Reconstitute using sterile laboratory-grade solvent

Avoid repeated freeze-thaw cycles

⚠️ Important Disclaimer

For research purposes only

Not for human consumption

Not intended to diagnose, treat, cure, or prevent any disease